Endocrine Abstracts

Hypersensitivity of hypothalamic–pituitary–adrenal (HPA) axis is considered to be an important factor in the pathogenesis of depression. Interestingly, glucagon-like peptide-1 (GLP-1) – an incretin hormone involved in the maintenance of glucose homeostasis in the periphery is known to activate HPA axis. The aim of the present study was to investigate whether prenatal stress (an animal model of depression) may influence levels of GLP-1 and GLP-1 receptor (GLP-1R)...